Senyawa Disobinin yang Bersifat Antimalaria dari Biji Tumbuhan Chisocheton macrophyllus (Meliaceae)

Nurlelasari Nurlelasari, Desi Harneti PH, Unang Supratman

Abstract


Disobinin compounds have been isolated from the seeds Chisocheton macrophyllus (Meliaceae). The chemical structure of compounds disobinin identified based on data covering UV spectroscopy, IR, 1D-NMR, 2D-NMR and mass spectra as well as the comparison with the data obtained from the literature. Disobinin compound showed antimalarial effect against P. falcifarum with IC50 values from 0.001 to 0.01 mg/mL . Limonoids compound, disobinin reported for the first time in the genus of Chisocheton.


Keywords


Meliaceae; Chisocheton Macrophyllus; Disobinin; Limonoids; Antimalarial

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References


Awang, K., Lim, C.S., Mohamad K., Morita, H., Hirasawa, Y., Takeya, K., Thoison, O.,and Hadi, A.H.A., 2007.

Erythrocarpines A-E, new cytotoxic limonoids from Chisochetonerytrocarpus, Bioorg Med Chem, 15: 5997-6002.

Bray, D.H., Warhurst, D.C., Conolly, J.D., O’Neil, M.J., and Philipson, J.D., 1990, Plants as source of antimalarial drug. Pt. 7 activity of some species Meliaceae plants and their constituent limonoids. Phytother Res, 4:29-35.

Heyne, K., 1987, The Useful Indonesian Plants, Research and Development Agency, Ministry of Forestry, Jakarta Indonesia.

Inada, A., Sukemawa, M., Murata, H., Nakanishi, T., Tokuda, H., Nishino, H., Iwashima, A., Darnaedi, D.,and Murata, J.,1993, Phytochemical studies on Maleaceous Plant. Part VIII. Structures and Inhibitory Effects on Epstein-Barr Virus Activation of Triterpenoids from Leaves of Chisocheton macrophyllus King, Chem Pharm Bull, 41: 617-619.

Laphookhieo, S., Maneerat, W., Koysomboon, S., Kiattansakul, R., Chantrapromma, K.,and Syers, J.K., 2008. A Novel Limonoid from the seeds of Chisocheton siamensis,Can J Chem,86: 205-208.

Maneerat, W., Laphookhieo, S., Syers, J.K., Kiattansakul., Koysomboon, S., and Chantrapromna, K., 2008, Antimalaria, Antimicobacterial and Cytotoxic limonoid from Chisocheton siamensis, Phytomedicine,15: 1130-1135.

Mohamad, K., Hirasawa,Y., Lim C.S., Awang, K., Hamid, A., Hadi, A., Takeya, K.,and Morita, H.,2008, Ceramicines A and walsogyne A novel limonoids from two species of Meliaceae, Tetrahedron Letter, 49: 4276–4278.

Mohamad, K., Hirasawa,Y., Litaudon, M., Awang, K., Hamid, A., Hadi, A., Takeya, K., Ekasari, W., Widyawaruyanti, A., Zaini, N.C.,and Morita, H.,2009, Ceramicines B–D, new antiplasmodial limonoids from Chisocheton ceramicus, Bioorganic & Medicinal Chemistry, 17: 727-730.

Omar, S., Zhang, J., MacKinnon, S., Leaman, D., Durst, T., Philogene, BJ., Anarson, JT., Sanchez-Vindas, PE., Poveda, L., Tamez, PA.,and Pezzuto, JM., 2003, Traditionally-used antimalarials from Meliaceae, Curr Top Med Chem,3(2): 133-9.

Parmar, B.S., 1995, Results with commercial neem formulations produced in India. In H. Schmutterer (ed.), The neem tree Azadirachtaindica A. Juss. And other Meliaceous plants. Sources of unique natural products for integrate pest managemant, medicine, industry and other purposes, VCH Tokyo, pp. 453-470.

Phongmaykin, J., Kumamoto, T., Ishikawa, T., Suttisri, R,, and Saifah, E., 2008. A New Sesquiterpene and Other Terpenoid Constituents of Chisochetonpenduliflorus, Arch Pharm Res,31: 1.

Wong, C.P., Shimada, M., Nagakura, Y., Nugroho, A.E., Hirasawa, Y., Kaneda, T., Awang, K., Hamid, A., Hadi, A., Mohamad, K., Shiro, M.,and Morita, H., 2011, Ceramicines E-I, New Limonoids from Chisocheton ceramicus, Chem Farm Bull,59: 407-411.

Yang, MH., Wang, JS., Luo, JG., Wang, XB.,and Kong, LY., 2009, Tetranortriterpenoids from Chisocheton paniculatus, Journal Nat Pro,72: 2014-2018.

Yang, M.H., Wang J.S., Luo J.G., Wang X.B., and Kong L.Y., 2011.

Chisopanins A-K, 11 New newprotolimonoids from Chisocheton paniculatus and their anti-inflammatory activities, Bioorganic & Medicinal Chemistry,19: 1409-1417.




DOI: https://doi.org/10.24252/al-kimia.v4i2.1675

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