Sintesis N-p-Metilbenzil-p-Kumaramida dari Asam p-Kumarat

Nasriadi Dali, Arniah Dali

Abstract


N-p-Methylbenzyl-p-coumaramide has been synthesized from p-coumaric acid. The purpose of this study was to synthesize N-p-methylbenzyl-p-coumaramide compounds from p-coumaric acid. The N-p-methylbenzyl-p-coumaramide target compound was obtained by direct conversion method using a orthoboric acid catalyst. Target compounds were identified and characterized by melting point, TLC test, FTIR, 1H-NMR, and 13C-NMR spectrometer. The results showed that N-p-methylbenzyl-p-coumaramide compound obtained was white solid (yield 75.83%) with melting point 156-158 oC and TLC (SiO2, n-hexane : chloroform = 5: 3 v/v, Rf = 0.37).


 


Keywords


Acylation; Amides; Amidation; Amines; Pcoumaric acid; Acylation; Amidation

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References


Firdaus, Soekamto, N. H., & Karim, A. (2009). Sintesis senyawa p-hidroksiamida dari asam p-hidroksisinamat melalui reaksi esterifikasi dan amonolisis. J. Chemica Acta. Vol. 2, 2-8.

Firdaus, Soekamto, N. H., Umar, U., Dali, S., Makmun, & Agustiningsih, A. (2011). Sintesis derivate senyawa p-kumaramida dan uji bioaktivitasnya terhadap sel kanker leukimia P-388. Laporan Penelitian. FMIPA UNHAS, Makassar.

Ilyas, A. (2008). Isolasi dan identifikasi metabolit sekunder dari ekstrak etilasetat kulit akar tumbuhan Kleinhovia hospita Linn (paliasa) dan uji toksitasnya terhadap Artemia salina Leach. Tesis. Program Pascasarjana Unhas, Makassar.

Kemp, W. (1991). Organic Spectroscopy. 3rd Edition. MacMillan Education Ltd., London.

Lambert, J.B., Gronert, S., Shurvell, H.F., & Lightner, D.A. (2011). Organic Structural Spectroscopy. 2nd ed.. New Jersey, Pearson Prentice Hall.

Matta, M. S., Wilbraham, A. C., & Staley, D. D. (1996). Introduction to Organic and Biological Chemistry. Lexington , D. C. Heath and Company.

Rasyid, H. (2014). Sintesis metil -(p-hidroksifenil)akrilat dan metil -(p-metoksifenil)akrilat serta uji bioaktivitas terhadap sel tumor P-388. Skripsi. FMIPA Unhas, Makassar.

Shargel, L., Yu, A., & Wu-Pong, S. (2004). Applied Biopharmaceutics and Pharmacokinetics. 5th ed. New York, McGraw Hill Professional.

Tang, P. (2005). Boroc acid catalyzed amide formation from carboxylic acid and amines n-benzyl-4-phenylbutyramide. J. Organic Syntheses. Vol. 81, 262-267.




DOI: https://doi.org/10.24252/al-kimia.v5i2.3643

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Al-Kimia, p-ISSN : 2302-2736, e-ISSN : 2549-9335
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