Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P

  • Isriany Ismail Universitas Islam Negeri Alauddin
  • M. Asrah Hidayah Usman
  • Nur Ida


Captopril have good absorption in gastric pH and ionized on intestinal pH. It is necessary to keep the drug in the form of molecules in the area of the absoption. The mucoadhesive gastroretensive drug delivery system provides the possibility of controlled release in stomach in a certain amount of time. Research has been conducted to assess the quality and profile of captopril release in of a mucoadhesive gastroretensive tablet. Mucoadhesive tablets (MK) were made in 5 formulas by wet granulation method using carbopol 934P and sodium carboxymethyl cellulose as matrix with ratio 10: 0 (MK1), 0: 10 (MK2), 5: 5 (MK3), 7: 3 (MK4), and 3: 7 (MK5). The parameters which was evaluate were characteristics of granules and tablets and kinetics model of captopril release from tablets in 0,01 N HCl medium. Mucoadhesive tablets had different characteristics for each formula. Mucoadhesive tablets that had good quality and release profile were shown by MK4 and MK5 formula. They had controlled drug release profiles accorded to the Korsmeyer-Peppas and Higuchi kinetics models, respectively.


Download data is not yet available.

Author Biography


Anil, A., & Sudheer, P. (2018). Mucoadhesive Polimers: A. Review. Journal of Pharmaceutical Research, 17(1), 48-55.

Anonim. (1979). Farmakope Indonesia Edisi III. . Jakarta: Departemen Kesehatan RI.

Ansel, H. C. (2008). Pengantar Bentuk Sediaan Farmasi Edisi 4 . Jakarta: UI Press.

Aulton, M. E. ( 1971). Pharmaceutics The Science Of Dosage Form Design (2nd ed., Vol. 6; A. M.E., ed.). Churchill livingstone.

Çelik, B. (2017). Risperidone Mucoadhesive Buccal Tablets: Formulation Design, Optimization, and Evaluation. Drug, Design, Development, and Therapy, II, 3355-3365.

da Silva, J. B., de Souza Ferreira, S. B., de Freitas, O., & Bruschi, M. L. (2017). A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems. Drug Development and Industrial Pharmacy, 43(7), 1053–1070.

Fernandes, C., Rasvita, G., & Gude, R. (2017). Formulation and Evaluation of Novel Gastroretentive Mucoadhesive Microspheres of Cyproheptadine Hydrochloride for Sustained Release. . World Journal of Pharmaceutical Research, 6(8), 2311–2322.

G., S., Chowdary, K. P., & Muralidhar, A. (2017). Preclinical Pharmacokinetic Evaluation of Captopril Floating Tablets Formualted Using Cross Linked Starch Urea - a New Modified Starch. World Journal of Pharmacy and Pharmaceutical Sciences, 6(4).1472–1486.

John, D., Roy, A., & Ramamurthy, J. (2019). Nanoparticles for Oral Transmucosal Drug Delivery – A Review. Journal of Pharmaceutical Science and Research, 11(12), 3712-3716.

Lachman, L. d. (2007). Teori Dan Praktek Farmasi Industri. jakarta: UI-Press.

Lopes, C. M., Bettencourt, C., Rossi, A., F, B., & Barata, P. (2016). Overview on gastroretentive drug delivery systems for improving drug bioavailability. International Journal of Pharmaceutics,, 510(1), 144–158.

Mansuri, S., Kesharwani , P., Jain, K., Takade, R., & Jain, N. (2016). Mucoadhesion: A promising approach in drug delivery system. Reactive and Functional Polymers , 100, 151–172.

Osman, Z., Adam, N., Hassan, H., & Nur, A. (2019). Influence of Binding Solution Concentration, Drying Duration and Drying Temperature on Physicochemical Performance of Norfloxacin Granul and Tablets. International Journal of Pharmacy and Pharmaceutical Sciences, 11(10), 71-79.

Parrott, E. L. (1971). Pharmaceutical Technology: Fundamental Pharmaceutics. Minneapolis.: Burgess Publishing.

Patil, H., Tiwari, R., & Repka, M. (2016). Recent advancements in mucoadhesive floating drug delivery systems: A mini-review. Journal of Drug Delivery Science and Technology , 31, 65-71.

Pratiwi, M., & Hadisoewignyo, L. (2010). Optimasi formula tablet lepas lambat kaptopril. Majalah Farmasi Indonesia, 21(4), 285 – 295.

Rajput, G., Majmudar, F., Patel, J., Patel, K., Thakor, R., Patel, B., et al. (2010). Stomach Specific Mucoahesive Tablet As Controlled Drug Delivery Systems- A Review Work. International Journal Of Pharmaceutical And Biological Reaserch, 1(1), 2010, 30-41.

Reddy, M. S., & Jalajakshi, B. (2018). Formulation and Evaluation Sustained Release Mucoadhesive Gastroretentive Pantoprazole Sodium Sesquihydrate Tablets for Anti–Ulcer. Journal of Drug Delivery and Therapeutics, 8(6-s), 304–310.

Russo, E., Selmin, F., Baldassari, S., Gennari, C., Caviglioli, G., Cilurzo, F., et al. (2016). A focus on mucoadhesive polymers and their application in buccal dosage forms. Journal of Drug Delivery Science and Technology, 32,113-125.

Shirodker, A., Gude , R., Acharya, S., Parab , S., Gadi , N., & Verekar , A. (2018). Formulation and Evaluation of Gastroretentive Mucoadhesive Tablets of Nizatidine. International Journal of Research In Pharmaceutical Sciences, 10(1), 31-39.

Simran S., P., Prashant S, M., & Santo, S. (2019). .Formulation and Evaluation of Sustained Release Matrix Tablets of Captopril. Journal of Drug Delivery & Therapeutics, 9(4-A), 260–268.

Suprianto. (2016). Analisis Kinetika Pelepasan Obat Teofilin dari Granul Matriks Kitosan. . Jurnal Ilmiah Manuntung, 2(1), 70–80.

Sweetman, S. (2007). Martindale: The Complete Drug Reference. Great Britain: Pharmaceutical Press.

Voigt, R. (1995). Buku Pelajaran Teknologi Farmasi 5th ed. terj. Yogyakarta: Gajah Mada University Press.

How to Cite
Ismail, I., Usman, M. A. H., & Ida, N. (2020). Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P. Ad-Dawaa’ Journal of Pharmaceutical Sciences, 3(1). https://doi.org/10.24252/djps.v3i1.14028
Abstract viewed = 793 times