Effectiveness Of Cassia alata L Leaf Extract Decrease Blood Glucose Level On Streptozotocin-Induced Male White Rats
Introduction: Diabetes mellitus (DM) is a condition in which the body either fails to produce enough insulin at the right time or fails to use it properly. Aims: The goal of this study is to show how Cassia alata L. leaf extract affects blood glucose levels in streptozotocin-induced diabetic rats. Methods: Cassia alata L. leaves therapy is an alternative treatment for DM. In this investigation, laboratory techniques were employed. Streptozotocin was administered intraperitoneally to mice at a dose of 40 mg/kg body weight initially. Except that they produce normal controls. Six groups of 30 rats each received treatment with Cassia alata L. leaf extract at doses of 500 mg/kg body weight, 600 mg/kg body weight, and 700 mg/kg body weight in addition to the usual control group. Trial outcome data were first examined using one-way ANOVA to confirm differences between treatments and then put through the DUNCAN trial. Result: As a result, it was discovered that secondary metabolites of alkaloids, flavonoids, saponins, and tannins were present in the ethanol extract of Cassia alata L. leaves. A dose of 700 mg/kg body weight is an effective blood sugar-lowering dose, with an average reduction of 121 mg/dl. Conclusion: Ethanol extract from Cassia alata L. leaves has this effect.
Dewi, Niluh Puspita., Windi Olivia Kawanga & Debora Rislianti Lakiu. (2022). Histopathological Study of Streptozotocin-Induced Liver Regeneration of Wistar RatsAfter Administration of Pumpkin Leaf Ethanol Extract. Ad-Dawaa'JournalofPharmaceuticalSciences, 4(2). pp.99-107
Haryoto, Nurhardianti, N., Sujono, A. T., Suhendi, A., & Muhtadi. (2016). Antidiabetic Mellitus Ethanol Extract of Stem Bark of Sala Plant (Cynometra ramiflora L.) Against Alloxan-Induced Wistar Male Rats. Research Journal of Pharmacy and Technology, 152(3), 28.
Herlina, Amriani, A., Solihah, I., Damayanti, P., & Rais, S. W. (2019). Effectiveness of Ethanolic Extract Ketepeng cina Leaves (Senna alata L.) As Antidiabetic Activity Test in Male Wistar Rats Induced by Alloxan. Journal of Physics: Conference Series, 1282(1).
Husna, F., Suyatana, F. D., Arozal, W., & Purwaningsih, E. H. (2019). Pharmaceutical Sciences & Research. Experimental Animal Models in Diabetes Research.
Kartini, S., & Rz, I. O. (2021). Lysis Test of Ascaris lumbricoides Eggs After Giving Ethanol Extract of Chinese Ketepeng Leaves (Cassia alata L.). Journal of Health Protection, 9(2), 9–15.
Oladeji, O. S. (2020). Ethnobotanical Description and Biological Activity of Senna alata. 1–20.
Saputra N. T. (2018). Streptozotocin Diabetagonic Agent To Make Male White Rats Diabetes Mellitus. Udayana Veterinary Bulletin. 10(2). 116-121
Setiawan, A.M. (2018). Activity Test of Eggplant (Solanum torvum Swartz) Fruit Extract Fraction on Decreased Blood Glucose Levels of Male White Rats (Rattus norvegicus) Induced by Streptozotocin. In Skirpsi
Tandy, Joni. (2018). Analysis of Red Gedi Leaves (Abelmoschus manihot (L) Medik) as a Medicine for Diabetes Mellitus (pp. 8-16). EGC Medical Book.
Tandi., Rizaldy, L., Siti, N., Magfirah, Yunlis, S. Kenta, & Ronaldy, N. (2020). Potential Test for Diabetic Nephropathy of Red Betel Leaves (Piper croatum Ruiz & Pav) in Male White Rats (Rattus norvegicus). Pharmacology: Journal of Pharmacy, 6(3), 239–251
Yani, S., & Iskandar, S. (2020). Effect of Chinese ketepeng leaves (Cassia alata L.) with a mixture of salt and whiting on the healing of fungal-infected skin in Wistar rats (Rattus norvegicus). 4.
Once an article was published in the journal, the author(s) are:
- granted to the journal right licensed under Creative Commons License Attribution that allows others to share the work with an acknowledgement of the work's authorship.
- permitted to publish their work online in third parties as it can lead to wider dissemination of the work.
- continue to be the copyright owner and allow the journal to publish the article with the CC BY-NC-SA license
- receiving a DOI (Digital Object Identifier) of the work.