Potential of Native and Pregelatinized Yellow Sweet Potato Starch as Binders in Fenofibric Acid Tablets via Wet Granulation

Potensi Pati Ubi Jalar Kuning Alami dan Pregelatinasi sebagai Bahan Pengikat Tablet Asam Fenofibrat dengan Metode Granulasi Basah

Abstract

Introduction: Sweet potato starch has potential as a pharmaceutical excipient. Aims: This study aimed to evaluate the potential of native and pregelatinized yellow sweet potato starch as binders in tablet formulations prepared by the wet granulation method. Method: The starch was extracted and pregelatinized, then incorporated at concentrations of 10%, 12.5%, and 15%. Granules and tablets were evaluated for particle size, flow rate, angle of repose, compressibility index, Hausner ratio, porosity, moisture content, weight and size uniformity, hardness, friability, abrasion, and disintegration time. Result: The results show that both native and pregelatinized starch produce tablets of comparable quality, with no significant differences between them. However, the 10% concentration does not perform optimally as a binder in either type of starch. The best tablet characteristics are observed at the 15% concentration, meeting pharmacopoeial standards in terms of hardness, friability, and disintegration. Conclusion: It is concluded that yellow sweet potato starch, in both native and pregelatinized forms, serves as a promising natural binder for wet granulation tablets, with 15% being the optimal concentration.