A Green Synthesis of Iron Oxide Nanoparticles Using Full Factorial Experimental Design: Technical and Analytical Impact of FeCl3.6H2O Precursor on Yield

Authors

  • Ben Haryan Adi Rogo IPB University
  • Khaneisya Luthfiyah Zahra IPB University
  • Nadia IPB University
  • Dian Pijar Mentari IPB University
  • Tyara Rhaima Putri IPB University
  • Rahmat Sidiq Suryakusuma IPB University
  • Novia Amalia Sholeha IPB University

Keywords:

ANOVA, Full factorial, IONPs, Pro-analytical, Technical

Abstract

Green synthesis of iron oxide nanoparticles (IONPs) has emerged as an eco-friendly alternative to conventional synthesis methods. This method utilizes natural ingredients, such as green tea extract, as a reducing agent that supports the green chemistry process. This research aims to analyze the effects of precursor concentration, reducing agent volume, and reaction temperature on
the synthesis results using technical and pro-analytical FeCl3.6H2O precursors. A full factorial design was employed to assess the effect of synthesis conditions on the IONPs yield. The yield was statistically analyzed using analysis of variance (ANOVA). The analysis results reveal that the predicted values are within reasonable consistency based on the experimental data of both IONPs from the technical
and pro-analytical precursors. The ANOVA values for both precursor sources show that the reaction temperature factor is negatively correlated, while the precursor concentration and reducing agent volume positively correlate with the IONPs yield. Regression model variance (ANOVA) can be explained 98.15% for the technical precursor model and 99.83% for the analytical precursor model
from data variations. This research can determine the optimal combination of synthesis factors that provide a basis for selecting a synthesis strategy tailored to specific performance requirements. These findings can support the wider application and reproducibility of green synthesis methods in various research contexts and implications for industry.

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Published

2025-06-29 — Updated on 2025-07-30

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How to Cite

Haryan Adi Rogo, B., Luthfiyah Zahra, K., Nadia, Pijar Mentari, D., Rhaima Putri, T., Sidiq Suryakusuma, R., & Amalia Sholeha, N. (2025). A Green Synthesis of Iron Oxide Nanoparticles Using Full Factorial Experimental Design: Technical and Analytical Impact of FeCl3.6H2O Precursor on Yield. Al-Kimia, 13(1). Retrieved from https://journal.uin-alauddin.ac.id/index.php/al-kimia/article/view/50900 (Original work published June 29, 2025)

Issue

Vol. 13 No. 1 (2025): JUNE

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