Synthesis of N-Benzenesulfonyl-p-Coumaramide from p-Coumaric Acid

  • Nasriadi Dali Jurusan Kimia FMIPA UHO Kendari
    (ID)
  • Arniah Dali Jurusan Pendidikam Kimia Fak. Ilmu Keguran dan Ilmu Kependidikan Univ. Halouleo
    (ID)

Abstract

N-Benzenesulfonyl-p-Coumaramide has been synthesized from  p-qumarid acid. This research aimed to synthesized  N-Benzenesulfonyl-p-Coumaramidefrom p-qumarid acid. Targeted coumpound obtained  from two steps reaction. Whice were amidation and asilation. Shynthesized product was identified and characterized by melting point, thing Layer Chromatography analysis, FTIR Spectrhophotometer,  1H-NMR, dan 13C-NMR. The result showed the obtained N-Benzenesulfonyl-p-Coumaramide was white solid ( yield 78.58 %) with melting point was 145-147 oC  and KLT (SiO2, n-hexane : cloroform = 6 : 4 v/v, Rf = 0.45).

Downloads

Download data is not yet available.

Author Biographies

Nasriadi Dali, Jurusan Kimia FMIPA UHO Kendari
Jurusan Kimia
Arniah Dali, Jurusan Pendidikam Kimia Fak. Ilmu Keguran dan Ilmu Kependidikan Univ. Halouleo
Jurusan Kimia

References

Anderson, J. E., Goetz, C. M., and McLaughlin, J. L. 1990. Blind Comparison of Simple Bench-top Bioassays and Human Tumour Cell Cytotoxicities as Antitumour Prescreen. J. Phytochemical Analysis. 6, 107-111.

Dali, N. 2016. Synthesis, Characterization, and Application of p-tert-Butylcalix[4]-and-[6]arena Derivative Compounds as Ionophores in Ion Selective Electrode (ISE) Coated Wire Type for Analysis of Hg Heavy Metal Content Hg(II) and Au(I). Dissertation Not Published. Graduate School of Unhas, Makassar.

Dali, N., and Dali, A. 2017. Synthesis of N-p-Methylbenzyl-p-Coumaramide from p-Coumaric Acid. Al-Chemy. Vol. 5, No. 2, 154-160.

Firdaus, Soekamto, N. H., and Karim, A. 2009. Synthesis of p-Hydroxyamide Compounds from p-Hydroxycinnamic Acid Through the Reaction of Esterification and Ammonolysis. J. Chemica Acta. Vol. 2, 2-8.

Firdaus, Soekamto, N. H., Umar, U., Dali, S., Makmun, and Agustiningsih, A. 2011. Synthesis of p-Coumaramida Derivative Compounds and their Bioactivity Test against Cancer Cell Leukemia P-388. Research Report. FMIPA Unhas, Makassar.

Ilyas, A. 2008. Isolation and Identification of Secondary

Metabolites from Ethyl Acetate Extracts of Root Skin of Kleinhovia hospita Linn (Paliasa) and Toxicity Test Against Artemia salina Leach. Thesis Not Published. Unhas Postgraduate Program, Makassar.

Matta, M. S., Wilbraham, A. C., and Staley, D. D. 1996. Introduction to Organic and Biological Chemistry. D. C. Heath and Company, Lexington.

Rasyid, H. 2014. Synthesis of Methyl -(p-hydroxyphenyl)

acrylate and Methyl -(p-Methoxyphenyl)acrylate and Bioactivity Test against P-388 Tumor Cells. Thesis Not Published. FMIPA Unhas, Makassar.

Shargel, L., Yu, A., and Wu-Pong, S. 2004. Applied Biopharmaceutics and Pharmacokinetics. 5th Edition. McGraw Hill Professional, New York.

Tang, P. 2005. Boroc Acid Catalyzed Amide Formation from Carboxylic Acid and Amines N-Benzyl-4-Phenylbutyramide. J. Organic Syntheses.81, 262-267.

Published
2018-12-24
How to Cite
Dali, N., & Dali, A. (2018). Synthesis of N-Benzenesulfonyl-p-Coumaramide from p-Coumaric Acid. Al-Kimia, 6(2), 113-119. https://doi.org/10.24252/al-kimia.v6i2.5891
Section
Article
Abstract viewed = 664 times