Mer Tirosin Kinase sebagai Situs Target Baru Pengobatan Leukemia
DOI:
https://doi.org/10.24252/jfuinam.v1i1.2095Abstract
Leukemia merupakan penyakit yang jarang terjadi, tetapi memiliki tingkat kematian yang sangat besar.Terapi leukemia dengan menggunakan kemoterapi memiliki efektivitas yang tinggi, tetapi memiliki toksisitas yang tinggi dan efek samping yang buruk. Metode alternatif dibutuhkan untuk menghasilkan terapi leukemia yang aman. Mer merupakan salah satu target baru pengobatan leukemia LLA. Kombinasi pengobatan inhibitor Mer dengan kemoterapi efektif menurunkan regimen dosis sehingga menurunkan efek samping.References
[1] Graham, D. K., Salzberg, D. B., Kurtzberg, J., Sather, S., Matsushima, G. K., Keating, A. K., Liang, X., Lovell, M. A., Williams, S. A., Dawson, T. L., Schell, M. J., Anwar, A. A., Snodgrass, H. R., Earp, H. S., 2006, Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Clin. Cancer Res., 12 (9), 2662-2669
[2] Huang, X., Finerty, P. Jr., Walker, J. R., Butler-Cole, C., Vedadi, M., Schapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., Dhe-Paganon, S., 2009, Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J. Struct. Biol. 165(2), 88-96
[3] Joseph T DiPiro, Robert L Talbert, Gary C Yee, Gary R Matzke, Barbara G Wells, and L Michael Posey, Pharmacotherapy: A Pathophysiologic Approach, 7th Edition Published by The McGraw-Hill Companies Inc., New York, NY, 2008. p.2259
[4] Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics 2008, CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96.
[5] Linger, R. M. A.; Keating, A. K.; Earp, H. S.; Graham, D. K. TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer. In Advanced Cancer Research; Academic Press: New York, 2008; Vol.100, pp 35−83.
[6] Liu, J., Yang, C., Simpson, C., DeRyckere, D.,Van Deusen,A., Miley, M.,J., Kireev, D., Norris-Drouin, J., Sather, S.,Hunter,D., Korboukh, V.K., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G.L., Earp, H.S., Graham, D.K., Frye, S.V., Wang, X., 2012, Discovery of SmALL Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia, Med. Chem. Lett., 3(2), 129-134
[7] Linger RM, Lee-Sherick AB, DeRyckere D, Cohen RA, Jacobsen KM, McGranahan A, Brandão LN, Winges A, Sawczyn KK, Liang X, Keating AK, Tan AC, Earp HS, Graham DK. Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia, Blood. 2013 Aug 29;122(9):1599-609
[2] Huang, X., Finerty, P. Jr., Walker, J. R., Butler-Cole, C., Vedadi, M., Schapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., Dhe-Paganon, S., 2009, Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J. Struct. Biol. 165(2), 88-96
[3] Joseph T DiPiro, Robert L Talbert, Gary C Yee, Gary R Matzke, Barbara G Wells, and L Michael Posey, Pharmacotherapy: A Pathophysiologic Approach, 7th Edition Published by The McGraw-Hill Companies Inc., New York, NY, 2008. p.2259
[4] Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics 2008, CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96.
[5] Linger, R. M. A.; Keating, A. K.; Earp, H. S.; Graham, D. K. TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer. In Advanced Cancer Research; Academic Press: New York, 2008; Vol.100, pp 35−83.
[6] Liu, J., Yang, C., Simpson, C., DeRyckere, D.,Van Deusen,A., Miley, M.,J., Kireev, D., Norris-Drouin, J., Sather, S.,Hunter,D., Korboukh, V.K., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G.L., Earp, H.S., Graham, D.K., Frye, S.V., Wang, X., 2012, Discovery of SmALL Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia, Med. Chem. Lett., 3(2), 129-134
[7] Linger RM, Lee-Sherick AB, DeRyckere D, Cohen RA, Jacobsen KM, McGranahan A, Brandão LN, Winges A, Sawczyn KK, Liang X, Keating AK, Tan AC, Earp HS, Graham DK. Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia, Blood. 2013 Aug 29;122(9):1599-609
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2017-01-31
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