Association Between Body Mass Index and Mortality in Patients With Tuberculosis-HIV Co-Infection in Asia and Africa

A Systematic Review and Meta-Analysis Protocol

Authors

  • Mufti As Siddiq M. Irzal Department of Epidemiology, University of Indonesia, Depok, Indonesia
  • Tri Yunis Miko Wahyono Department of Epidemiology, University of Indonesia, Depok, Indonesia
  • Putri Novia Choiri Insani Department of Nutrition, University of Indonesia, Depok, Indonesia
  • Welstin Wemi Loa Department of Epidemiology, University of Indonesia, Depok, Indonesia
  • Leopardo Alvalius Ngetwa Department of Biostatistics and Epidemiology, Muhimbili University of Health and Allied Science, Tanzania, East Africa

DOI:

https://doi.org/10.24252/al-sihah.v17i1.56107

Keywords:

body mass index, coinfection, hiv infections, medline, tuberculosis

Abstract

Globally, the prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection in 2019 was 8.2%. In 2020, TB-related deaths among individuals with HIV totaled 214,000, representing an increase from the previous year. Previous studies suggest that body mass index (BMI) is a significant predictor of mortality risk in individuals with TB and HIV co-infection, as malnutrition and low BMI are frequently linked to poorer clinical outcomes. This protocol has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A systematic review and meta-analysis will be conducted by searching three databases: MEDLINE/PubMed, Scopus, and ProQuest. This protocol aims to outline the stages and procedures of the forthcoming systematic review and meta-analysis, including the justification of the research question; the definition of Population, Exposure, Outcome, and Study design (PEOS); the inclusion and exclusion criteria; the search strategy; study screening and data extraction; and the planned data analysis. Identifying BMI as a prognostic factor through this study may inform nutrition-based interventions and treatment protocols aimed at reducing mortality among individuals co-infected with TB and HIV in Asia and Africa.


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References

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Published

2025-06-14

How to Cite

Irzal, M. A. S. M., Wahyono, T. Y. M., Insani, P. N. C., Loa, W. W., & Ngetwa, L. A. (2025). Association Between Body Mass Index and Mortality in Patients With Tuberculosis-HIV Co-Infection in Asia and Africa: A Systematic Review and Meta-Analysis Protocol. Al-Sihah: The Public Health Science Journal, 17(1), 23–32. https://doi.org/10.24252/al-sihah.v17i1.56107

Issue

Volume 17, Nomor 1, January-June 2025

Section

Article

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Copyright (c) 2025 Mufti As Siddiq M. Irzal, Tri Yunis Miko Wahyono, Putri Novia Choiri Insani, Welstin Wemi Loa, Leopardo Alvalius Ngetwa

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