Acute Antinflammatory Effect of Marsdenia Tinctoria Leaf Water Extract In Carragenan-induced Rats
Keywords:
Tarum areuy, Marsdenia tinctoria, water extract, anti-inflammatory, carrageenanAbstract
Introduction: Tarum areuy (Marsdenia tinctoria) is a plant whose efficacy has not been widely explored. Traditionally used for infections and inflammation related disease. Aims: To determine the anti-inflammatory effect of M. tinctoria leaf water extract on animals induced by carrageenan. Methods: Extract preparation by boiling in water. Animals were divided into groups, namely control, comparison (diclofenac sodium 4.5 mg/kgBW) and M. tinctoria leaf water extract (20, 40, 80 mg/kgBW). Induction of 0.1 mL of 1% carrageenan was given as much as intraplantar and the test preparation was given orally. Inflammatory and inflammatory inhibition percentages were measured every 30 minutes for 240 minutes. The t-test was utilized in data analysis. Result: All test doses of M. tinctoria leaf water extract was effective to reduce inflammation in comparison to the control (p<0.05). A dose of 20 mg/kgBW was the optimal anti-inflammatory. Conclusion: M. tinctoria leaf water extract has the potential as an anti-inflammatory.
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