Successful Multidrug Chemotherapy for Rhabdomyosarcoma in a Seven-Year-Old Girl: A Case Report

Authors

  • Arwini Avissa Abdullah Department of Pediatry, Faculty of Medicine, Hasanuddin University
  • Nadirah Rasyid Ridha Division of Hemato-oncology, Department of Pediatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.24252/alami.v8i1.39081

Keywords:

Case Report, Chemotherapy, Rhabdomyosarcoma

Abstract

The most frequent soft tissue cancer in children is rhabdomyosarcoma (RMS). A diagnosis typically occurs between the ages of 5 and 6 in women. We report a seven-year-old girl was referred to Hospitals with complaints of a protruding left eye. The swelling was presented in July 2021, which was small earlier but has increased and become more prominent. An examination of the left eyelid showed a 2.5 x 2.5 x 1.5 cm solid mass with edema, erythema, and secretion in the superior and inferior affected eyelid. A Head CT scan revealed a left superolateral lacrimal duct tumour with a normal intracerebral structure. The histopathology examination found dacryoadenitis with an RMS tumour. This patient was treated using the RMS multidrug chemotherapy protocol (vincristine, actinomycin, and cyclophosphamide) for three sessions, which decreased tumour progressivity five months later. Early and appropriate treatment of this patient with chemotherapy regimens according to the protocol for RMS has a good prognosis.

Author Biography

Nadirah Rasyid Ridha, Division of Hemato-oncology, Department of Pediatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Assistant Professor at Department of Pediatry

References

1. Ratnaningsih T, Hurimah W. Rhabdomyosarcoma metastases to the bone marrow of a 2-year-old male patient: A case report. JKKI J Kedokt Dan Kesehat Indones. Published online August 31, 2020:198-203. doi:10.20885/JKKI.Vol11.Iss2.art13
2. Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tsuchiya H. Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma. Cancers. 2020;12(7):1758. doi:10.3390/cancers12071758
3. Albalawi ED, Alkatan HM, Elkhamary SM, Safieh LA, Maktabi AMY. Genetic profiling of rhabdomyosarcoma with clinicopathological and radiological correlation. Can J Ophthalmol. 2019;54(2):247-257. doi:10.1016/j.jcjo.2018.03.011
4. Jurdy L, Merks JHM, Pieters BR, et al. Orbital rhabdomyosarcomas: A review. Saudi J Ophthalmol. 2013;27(3):167-175. doi:10.1016/j.sjopt.2013.06.004
5. Bravo-Ljubetic L, Peralta-Calvo J, Larrañaga-Fragoso P, Pascual NO, Pastora-Salvador N, Gomez JA. Clinical Management of Orbital Rhabdomyosarcoma in a Referral Center in Spain. J Pediatr Ophthalmol Strabismus. 2016;53(2):119-126. doi:10.3928/01913913-20160122-02
6. Kaseb H, Kuhn J, Babiker HM. Rhabdomyosarcoma. In: StatPearls. StatPearls Publishing; 2022. Accessed December 17, 2022. http://www.ncbi.nlm.nih.gov/books/NBK507721/
7. Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S. Orbital Rhabdomyosarcoma. Cancer Control. 2004;11(5):328-333. doi:10.1177/107327480401100507
8. Nicula C, Nicula D, Blidaru M, Ghiţuică A, Neamtu S, Saplonţai-Pop A. Orbital Rhabdomyosarcoma with a good life prognosis after surgical treatment in a 14-year-old patient. Open Med. 2014;9(3):394-399. doi:10.2478/s11536-013-0289-8
9. Terezakis SA, Wharam MD. Radiotherapy for Rhabdomyosarcoma: Indications and Outcome. Clin Oncol. 2013;25(1):27-35. doi:10.1016/j.clon.2012.07.009
10. Ning Z, Liu X, Qin G, Wei L, Li X, Shen J. Evaluation of clinical efficacy of Chemotherapy for Rhabdomyosarcoma in children. Pak J Med Sci. 2020;36(5). doi:10.12669/pjms.36.5.1829
11. Thien HH, Kim Hoa NT, Duy PC, Carlos RG, Son NH. Pediatric primary orbital rhabdomyosarcoma. J Pediatr Surg Case Rep. 2020;59:101475. doi:10.1016/j.epsc.2020.101475

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Published

2024-01-30

How to Cite

Abdullah, A. A., & Ridha, N. R. (2024). Successful Multidrug Chemotherapy for Rhabdomyosarcoma in a Seven-Year-Old Girl: A Case Report. Alami Journal (Alauddin Islamic Medical) Journal, 8(1), 56–62. https://doi.org/10.24252/alami.v8i1.39081

Issue

Section

Case Report