High Risk of Dyslipidemia in Obese Adolescents: Exploring the Factors and Implications for Cardiovascular Health

  • Ria Qadariah Arief UIN Sunan Ampel Surabaya
  • Linda Prasetyaning W Departement of Psychology, Faculty of Psychology and Heath, UIN Sunan Ampel, Indonesia
    (ID)
  • Maryam Jamila Arief Departement of Department of Pharmacology, Faculty of Pharmacy, Universitas Mulawarman, Indonesia
    (ID)
Keywords: Dyslipedemia, Adolescent, Obesity

Abstract

Dyslipidemia in obese adolescents is a marker of early-onset cardiovascular problems such as atherosclerosis. The purpose of this study was to identify the magnitude of the problem of dyslipidemia in obese adolescents. This study uses content analysis of literature reviews in synthesizing articles in accordance with the criteria and research objectives. This study uses Google Scholar, Pub Med using the keywords "Youth Dyslipidemia". Articles included in the inclusion criteria are original research, which measures cholesterol levels in adolescents. , whereas we were excluded if the articles contained narrative opinion articles, editorial comments, literatru reviews, and did not measure cholesterol levels in adolescents. The results from 18,900 articles we get about 8 articles of which 3 articles about dyslipidemia in adolescents with diabetes, 3 articles on dyslipidemia in healthy adolescents, and 2 articles on the magnitude of the problem of dyslipidemia in adolescents with lipid abnormalities. Adolescents who are obese have a high risk of developing dyslipidemia, which is a disorder of lipid metabolism. Dyslipidemia in obese adolescents contributes to atherosclerosis, namely the formation of plaque that settles in blood vessels and can cause cardiovascular disease.

References

Alrasheed, A. A. (2022). Dyslipidemia Among Patients With Type 1 Diabetes and Its Associated Factors in Saudi Arabia: An Analytical Cross-Sectional Study. Cureus, 14(2). Retrieved from https://doi.org/10.7759/cureus.21923

Alrasheed, A. A. (2022). Dyslipidemia Among Patients With Type 1 Diabetes and Its Associated Factors in Saudi Arabia: An Analytical Cross-Sectional Study. Cureus, 14(2).

Aubert, S., Brazo-Sayavera, J., González, S. A., Janssen, I., Manyanga, T., Oyeyemi, A. L., Picard, P., Sherar, L. B., Turner, E., & Tremblay, M. S. (2021). Global prevalence of physical activity for children and adolescents; inconsistencies, research gaps, and recommendations: A narrative review. International Journal of Behavioral Nutrition and Physical Activity, 18(1), 81. https://doi.org/10.1186/s12966-021-01155-2

Barberio, M. D., Kasselman, L. J., Playford, M. P., Epstein, S. B., Renna, H. A., Goldberg, M., DeLeon, J., Voloshyna, I., Barlev, A., Salama, M., Ferrante, S. C., Nadler, E. P., Mehta, N., Reiss, A. B., & Freishtat, R. J. (2019). Cholesterol efflux alterations in adolescent obesity: Role of adipose-derived extracellular vesical microRNAs. Journal of Translational Medicine, 17(1), 232. https://doi.org/10.1186/s12967-019-1980-6

Burlutskaya, A. V., Tril, V. E., Polischuk, L. V., & Pokrovskii, V. M. (2021). Dyslipidemia in pediatrician’s practice. Reviews in Cardiovascular Medicine, 22(3), Article 3. https://doi.org/10.31083/j.rcm2203088

Camargo, J. de S. A. A., Zamarchi, T. B. de O., Balieiro, A. A. da S., Pessoaa, F. A. C., & Camargo, L. M. A. (2021). Prevalence of obesity, high blood pressure, dyslipidemia and their associated factors in children and adolescents in a municipality in the Brazilian Amazon region. Journal of Human Growth and Development, 31(1), Article 1. https://doi.org/10.36311/jhgd.v31.11209

Cao, J., Zhang, L., Li, J., Sun, L., Liu, S., Zhang, J., & Zhao, H. (2020). Pubertal maturation and weight status are associated with dyslipidemia among children and adolescents in Northwest China. Scientific Reports, 10(1), Article 1. https://doi.org/10.1038/s41598-020-73507-0

Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism, 92, 6–10. https://doi.org/10.1016/j.metabol.2018.09.005

Dündar, İ., & Akıncı, A. (2022). Frequency of Dyslipidemia and Associated Risk Factors Among Obese Children and Adolescents in Turkey. Iranian Journal of Pediatrics, 32(3), Article 3. https://doi.org/10.5812/ijp-122937

Falaschetti, E., Hingorani, A. D., Jones, A., Charakida, M., Finer, N., & Whincup, P. (2010). Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children. Eur Heart J, 31. https://doi.org/10.1093/eurheartj/ehq355

Gooding, H. C., & de Ferranti, S. D. (2010). Cardiovascular risk assessment and cholesterol management in adolescents: Getting to the heart of the matter. Current Opinion in Pediatrics, 22(4), 398–404. https://doi.org/10.1097/MOP.0b013e32833a6e22

Haddaway, N. R., Page, M. J., Pritchard, C. C., & McGuinness, L. A. (2022). PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Systematic Reviews, 18(2), e1230. https://doi.org/10.1002/cl2.1230

Higgins, V., Asgari, S., Hamilton, J. K., Wolska, A., Remaley, A. T., Hartmann, B., Holst, J. J., & Adeli, K. (2020). Postprandial Dyslipidemia, Hyperinsulinemia, and Impaired Gut Peptides/Bile Acids in Adolescents with Obesity. The Journal of Clinical Endocrinology & Metabolism, 105(4), 1228–1241. https://doi.org/10.1210/clinem/dgz261

Huang, R.-C., Lillycrop, K. A., Beilin, L. J., Godfrey, K. M., Anderson, D., Mori, T. A., Rauschert, S., Craig, J. M., Oddy, W. H., Ayonrinde, O. T., Pennell, C. E., Holbrook, J. D., & Melton, P. E. (2019). Epigenetic Age Acceleration in Adolescence Associates With BMI, Inflammation, and Risk Score for Middle Age Cardiovascular Disease. The Journal of Clinical Endocrinology & Metabolism, 104(7), 3012–3024. https://doi.org/10.1210/jc.2018-02076

Kaestner, T. L., Santos, J. A. D., Pazin, D. C., Baena, C. P., Olandoski, M., Abreu, G. A., Kuschnir, M. C. C., Bloch, K. V., & Faria-Neto, J. R. (2020). Prevalence of Combined Lipid Abnormalities in Brazilian Adolescents and Its Association with Nutritional Status: Data from the Erica Study. Global Heart, 15(1), 23. https://doi.org/10.5334/gh.769

Kavey, R.-E. W. (2023). Combined Dyslipidemia. In A. Ashraf & B. Sunil (Eds.), Pediatric Dyslipidemia: A Practical Guide (pp. 63–71). Springer International Publishing. https://doi.org/10.1007/978-3-031-24113-0_7

Khoury, M., Bigras, J.-L., Cummings, E. A., Harris, K. C., Hegele, R. A., Henderson, M., Morrison, K. M., St-Pierre, J., Wong, P. D., & McCrindle, B. W. (2022). The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: A Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Clinical Practice Update. Canadian Journal of Cardiology, 38(8), 1168–1179. https://doi.org/10.1016/j.cjca.2022.05.002

Kim, G., DeSalvo, D., Guffey, D., Minard, C. G., Cephus, C., Moodie, D., & Lyons, S. (2020). Dyslipidemia in adolescents and young adults with type 1 and type 2 diabetes: A retrospective analysis. International Journal of Pediatric Endocrinology, 2020(1), 11. https://doi.org/10.1186/s13633-020-00081-7

Maffeis, C., Cendon, M., Tomasselli, F., Tommasi, M., Bresadola, I., Fornari, E., Morandi, A., & Olivieri, F. (2021). Lipid and saturated fatty acids intake and cardiovascular risk factors of obese children and adolescents. European Journal of Clinical Nutrition, 75(7), Article 7. https://doi.org/10.1038/s41430-020-00822-0

Merianos, A. L., Jandarov, R. A., Khoury, J. C., & Mahabee-Gittens, E. M. (2018). Tobacco Smoke Exposure Association with Lipid Profiles and Adiposity Among U.S. Adolescents. The Journal of Adolescent Health : Official Publication of the Society for Adolescent, 62(4), 463.

Miyamura, K., Nawa, N., Isumi, A., Doi, S., Ochi, M., & Fujiwara, T. (2021). The Association of Passive Smoking and Dyslipidemia Among Adolescence in Japan: Results From A-CHILD Study. The Journal of Clinical Endocrinology & Metabolism, 106(7), e2738–e2748. https://doi.org/10.1210/clinem/dgab094

Ogle, G. D., James, S., Dabelea, D., Pihoker, C., Svennson, J., Maniam, J., Klatman, E. L., & Patterson, C. C. (2022). Global estimates of incidence of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Atlas. Diabetes Research and Clinical Practice, 183.

Reuter, C. P., Brand, C., Silva, P. T. da, Reuter, É. M., Renner, J. D. P., Franke, S. I. R., Mello, E. D. de, Burgos, L. T., Schneiders, L. de B., & Burgos, M. S. (2019). Relationship between Dyslipidemia, Cultural Factors, and Cardiorespiratory Fitness in Schoolchildren. Arquivos Brasileiros de Cardiologia, 112, 729–736. https://doi.org/10.5935/abc.20190068

Selvaraj, M., Prasad, H. K., White, S., Prasanna, B., & Sangaralingam, T. (2023). Prevalence and Determinants of Occurrence of Dyslipidemia in Subjects with Type 1 Diabetes Mellitus. Indian Journal of Pediatrics, 90(2), 118–123. https://doi.org/10.1007/s12098-022-04130-2

Słomiński, B., Ławrynowicz, U., Ryba-Stanisławowska, M., Skrzypkowska, M., Myśliwska, J., & Myśliwiec, M. (2019). CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes. Cytokine, 114, 81–85. https://doi.org/10.1016/j.cyto.2018.11.005

Soliman, H., & Ibrahim, A. (2021). Prevalence and pattern of dyslipidemia in an Egyptian children and adolescents with type 1 diabetes. Egyptian Pediatric Association Gazette, 69(1), 21. https://doi.org/10.1186/s43054-021-00067-x

Stein, R., Ferrari, F., & Scolari, F. (2019). Genetics, Dyslipidemia, and Cardiovascular Disease: New Insights. Current Cardiology Reports, 21(8), 68. https://doi.org/10.1007/s11886-019-1161-5

Trautwein, E. A., & McKay, S. (2020). The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk. Nutrients, 12(9), Article 9. https://doi.org/10.3390/nu12092671

Xi, Y., Niu, L., Cao, N., Bao, H., Xu, X., Zhu, H., Yan, T., Zhang, N., Qiao, L., Han, K., Hang, G., Wang, W., & Zhang, X. (2020). Prevalence of dyslipidemia and associated risk factors among adults aged ≥35 years in northern China: A cross-sectional study. BMC Public Health, 20(1), 1068. https://doi.org/10.1186/s12889-020-09172-9

Yeung, E., Daniels, S. R., & Patel, S. S. (2021). Dyslipidemia in childhood and adolescence: From screening to management. Current Opinion in Endocrinology, Diabetes and Obesity, 28(2), 152. https://doi.org/10.1097/MED.0000000000000607

Published
2023-07-30
Section
Volume 3, Issue 2, 2023
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