Toleransi Osmotik Eritrosit Tikus Model DMT2 dengan Perlakuan Campuran Ekstrak Tempe Kedelai Hitam dan Ubi Jalar Ungu (In Press)

mustika ayu wulansari

Abstract


ABSTRACT

Type 2 diabetes mellitus (T2DM) due to ineffective use of insulin by the body so that the experience hipeglikemia. Hyperglycemia causes intracellular ion balance disorder causing changes in cell size and fragility of the cell membrane and results in circulatory system disorders. Black soybean tempe and purple sweet potato has a potential therapy for patients with T2DM. This study aims to determine the blood osmotic tolerance rat model of T2DM were given treatment of mixed soybean black tempe and purple sweet potato. Osmotic tolerance shown by the level of erythrocyte membrane damage that is crenation and hemolysis. This study aims to determine the blood osmotic tolerance of T2DM. Research results shows that chemical compounds such as drugs work better glibenclamide lowers damage to the cell membrane as compared to administration of a mixture of natural compounds soybean black tempe and purple sweet potato.

 

Keyword: osmotic tolerance, T2DM, black soybean tempe, purple sweet potato

 

INTISARI

Diabetes mellitus tipe 2 (DMT2) disebabkan penggunaan insulin yang kurang efektif oleh tubuh sehingga mengalami hipeglikemia. Hiperglikemia menyebabkan gangguan keseimbangan ion intraseluler sehingga menyebabkan perubahan ukuran sel dan kerapuhan membran sel dan berakibat pada gangguan sistem sirkulasi. Tempe kedelai hitam dan Ubi Jalar Ungu memiliki potensi terapi bagi penderita DMT2. Penelitian ini bertujuan mengetahui toleransi osmotik darah tikus model DMT2 yang di berikan perlakuan campuran ekstrak tempe kedelai hitam dan ubi jalar ungu. Toleransi osmotik ditunjukkan dengan tingkat kerusakan membran eritrosit yaitu krenasi dan hemolisis. Hasil Penelitian menunjukkan bahwa pemberian senyawa kimia berupa obat glibenklamid bekerja lebih baik menurunkan kerusakan membran sel dibandingkan dengan pemberian senyawa alami campuran ekstrak tempe kedelai hitam dan ubi jalar ungu

 

Kata kunci: toleransi osmotik, DMT2, tempe kedelai hitam, ubi jalar ungu




DOI: https://doi.org/10.24252/bio.v6i1.4236

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Biogenesis: Jurnal Ilmiah Biologi
pISSN 2302-1616
eISSN 2580-2909

Published by
Department of Biology, Faculty of Science and Technology, Alauddin State Islamic University
Jl.H.M.Yasin Limpo No. 36 Samata, Gowa, South Sulawesi, Indonesia

Email: biogenesis@uin-alauddin.ac.id
WA: +6285242001984
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Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.