Preparation of Telmisartan Orally Disintegrating Tablets Based on Microencapsulation
DOI:
https://doi.org/10.24252/djps.v9i1.65617Keywords:
Telmisartan, microencapsulation, orally disintegrating tablet, sodium starch glycolate, dissolutionAbstract
Introduction: Telmisartan is an angiotensin II receptor blocker widely prescribed for hypertension management. As a Biopharmaceutics Classification System class II drug, it exhibits low aqueous solubility, which may limit its dissolution rate and oral absorption. Conventional tablets may also present swallowing difficulties, particularly in pediatric and geriatric patients. Aims: This study aimed to develop a microencapsulated telmisartan formulation incorporated into an orally disintegrating tablet (ODT) system to enhance dissolution behavior and optimize tablet characteristics. Result: Telmisartan was microencapsulated using the solvent evaporation method with Eudragit L100 at a 1:1 ratio and characterized by particle size analysis, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. ODTs were prepared by direct compression using sodium starch glycolate and evaluated for weight uniformity, hardness, friability, wetting time, disintegration time, and dissolution profile. Microencapsulation reduced particle size from 0.930 µm to 0.816 µm and decreased crystallinity. The tablets exhibited acceptable physical properties, including weight uniformity of 241.5 ± 2.6 mg, hardness of 2.4 ± 0.49 kg/cm², friability of 0.10 ± 0.02%, and a disintegration time of 26.83 ± 1.47 s. Dissolution testing showed a higher release rate for ODT compared with the conventional tablet, reaching 54.46% at 2 minutes and 62.12% at 5 minutes. Conclusion Microencapsulation combined with an ODT system improved the physicochemical characteristics and dissolution performance of telmisartan without compromising tablet quality.
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