• Isma Fadlilatus Sa'diyah Medical Faculty of Lampung University


Malaria is a major public health problem in the world, especially in Indonesia. The prevalence of malaria in Indonesia reaches 6 percent, which is mostly caused by plasmodium falciparum. Various treatment options for malaria falciparum have been developed, but due to various factors, such as the adherence to taking medication from patients are not monitored so that it can increase the risk of resistance to current malaria therapy. Therefore, the researchers conducted further research on alternative malaria therapies. Cinnamomum verum or cinnamon is known to contain cinnamaldehyde compounds which have an antimicrobial effect. The purpose of this study was to determine the anti-microbial effect of Cinnamomum verum extract or cinnamon extract as adjuvant therapy in malaria falciparum. This type of study is a literature review with the method of collecting reading results from 25 articles of case reports, research articles, and literature reviews. This study concludes that the cinnamaldehyde compound in Cinnamomum verum extraction has an antimicrobial effect which can inhibit the denaturation potential of amino acids, inhibits β-hematin formation and activity of the reductase enzyme on Plasmodium falciparum enoyl-ACP reductase, where it is known that these four have an important role. in the pathogenesis of falciparum malaria.


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Attieh H, Abulafi SA, Jaber S, Abouremeleh QM. Cinnamon bark water-infusion as an in-vitro inhibitor of β -hematin formation. J Med Plants Res. 2015;9(38)(November):998–1005.

Bartoloni A, Zammarchi L. Clinical aspects of uncomplicated and severe malaria. Mediterr J Hematol Infect Dis. 2012;4(1).

Elyazar IRF, Gething PW, Patil AP, Rogayah H, Kusriastuti R, Wismarini DM, et al. Plasmodium falciparum malaria endemicity in indonesia in 2010. PLoS One. 2011;6(6):1–13.

Anberber S, Tessema T, Yimer A. Severe malaria in the under-fives - Clinical features, management and outcome in a district hospital. Ethiop Med J. 2003;41(4):301–10.

Pusat Data dan Informasi, Direktorat Pengendalian Penyakit Bersumber Binatang. Epidemiologi Malaria di Indonesia. Bul Jendela Data dan Inf Kesehat. 2011;1:1–16.

Hakim L. Malaria : Epidemiologi dan Diagnosis. Aspirator. 2011;3(2):107–16.

Rehman AM, Coleman M, Schwabe C, Baltazar G, Matias A, Gomes IR, et al. How much does malaria vector control quality matter: The epidemiological impact of holed nets and inadequate indoor residual spraying. PLoS One. 2011;6(4).

World Health Organization. Safety of 8-aminoquinoline antimalarial medicines. 2014.

Priantono D, Purnama A, Nelwan EJ. Tantangan dalam Tata Laksana Malaria Berat di Rumah Sakit Daerah Terpencil di Indonesia Challenges in Providing Treatment of Severe Malaria Case in a District Hospital of Remote Area in Indonesia. J Penyakit Dalam Indones. 2016;3(1):41–4.

World Health Organization. Malaria. Int Travel Heal. 2016.

A. H. Cahyana, W. Wibowo, A. Pratama, and B. Ardiansah. Synthesis, characterization and anti-oxidative properties of propolis-like compound prepared from prenylation of Indonesia’s cinnamon (CinnamomumBurmannii) essential oil using -Al2O3/NaOH/Na. J Chem Pharm Res. 2015;7(1):715–9.

Talapko J, Škrlec I, Alebić T, Jukić M, Včev A. Malaria: The past and the present. Microorganisms. 2019;7(6).

Center of Disease Control. CDC’s Malaria Program. Cent Glob Heal Div Parasit Dis Malar. 2015;1–2.

Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia. Vol. 70, Kesehatan. Jakarta: Kementerian Kesehatan Republik Indonesia; 2016. 1780–1790 p.

Kementerian Kesehatan Republik Indonesia. Pedoman Penatalaksanaan Kasus Malaria di Indonesia. Jakarta: Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan; 2017.

Suryani E, Purwiyanti S, Blume C, Nees C, Blume. The Growth , Productivity and Quality of Fifteen Accessions of Ceylon Cinnamon at Medium Elevation of Solok , West Sumatera. 2017;28(2):105–12.

Joshi, B., Lekhak, S. & Sharma A. Antibacterial Property Of Different Medicinal Plants: Ocimum sanctum, Cinnamomum zeylanicum, Xanthoxylum armatum and Origanum majorana. Kathamandu Univ J Sci Eng. 2009;

Ranasinghe, P., Pigera, S., Premakumara, G., Galappaththy, P., Constantine, G. & Katulanda P. BMC Medicinal Properties of True Cinnamon (Cinnamomum zeylanicum) : a. Systematic Review. Complementary and Alternative Medicine. BMJ. 2013;

Departemen Pertanian Direktorat Jendral Perkebunan. Pedoman Teknis Budidaya Kayumanis. 2008.

Interagency Taxonomic Information System. Cinnamomum verum. 2020.

Rao PV, Gan SH. Cinnamon: A multifaceted medicinal plant. Evidence-based Complement Altern Med. 2014;2014.

Asadollahi A, Khoobdel M, Ramazani AZ, Azarmi S. Effectiveness of plant ‑ based repellents against different Anopheles species : a systematic review. Malar J [Internet]. 2019;1–20. Available from: https://doi.org/10.1186/s12936-019-3064-8

René E, Nkanwen S, Awouafack MD, Jules J, Bankeu K, Wabo HK, et al. Constituents From the Stem Bark of Cinnamomum zeylanicum Welw . ( Lauraceae ) and Their Inhibitory Activity Toward Plasmodium falciparum Enoyl-ACP Reductase Enzyme. 2013;4:296–301.

Parvazi S, Sadeghi S, Azadi M, Mohammadi M, Arjmand M, Vahabi F, et al. The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1 HNMR Spectroscopy. 2016;2016.

Arias V, Arias CAV, Castro LE, Obando JG, Sáenz FE. Diverse origin of Plasmodium falciparum in northwest Ecuador. Malar J [Internet]. 2019;1–11. Available from: https://doi.org/10.1186/s12936-019-2891-y

Mawson AR. The pathogenesis of malaria : a new perspective. 2013;

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